◎原 名 Principles
ofBiochemicalToxicology,FourthEdition◎出版时间 2008年11月18日◎国 家 美国◎类 别 教育科技-医学◎版 本 第四版◎语 言 英文◎文件格式 PDF◎文件大小 11.7MB◎页 码 453页◎作 者 JohnA.Timbrell◎内容简介：
这在该领域处于领先地位的教科书对毒性机制进行了研究，特别是在分子和因子方面对毒性研究起到了决定性的影响。新版本更新，以反映到生物化学基础上的最新研究和对药物的不利影响，环境污染，职业危害日益关注。《生化毒理学原理第四版》彻底解释剂量反应关系，处置和代谢，以及外国化合物的毒性反应，并列出了详细的例子，对在毒性机制方面学生首次更容易遇到的问题做出明确的讲解。内容全面、简洁、明快，内容包括概要部分，问题和标准答案，并完全的修正了原作品，作为一个不可或缺的辅助学习和教学服务。
Thisleadingtextbookinthefieldexaminesthemechanismsunderlyingtoxicity,particularlytheeventsatthemolecularlevelandthefactorsthatdetermineandaffecttoxicity.Theneweditionisupdatedtoreflectthelatestresearchintothebiochemicalbasisoftoxicologyandthegrowingconcernsovertheadverseeffectsofdrugs,environmentalpollution,andoccupationalhazards.PrinciplesofBiochemicalToxicology,FourthEditionthoroughlyexplainsdose-responserelationships,dispositionandmetabolism,andtoxicresponsestoforeigncompounds,andpresentsdetailedexamplestomakethemechanismsoftoxicitymoreaccessibletostudentsencounteringthesubjectforthefirsttime.Comprehensiveinscopewithaclearandconciseapproach,thetextincludessummarysections,questionsandmodelanswers,andthoroughlyrevisedartworkthatservesasanessentialaidtolearningandteaching.NewtotheFourthEdition:reorganizedsectionsthatcoverbasicprinciplesfollowedbysectionsondifferenttypesoftoxicityextensiveuseofexamplesthroughoutandnumerousexplanatorydiagramsnewmaterialonriskassessment,exportsystems,oxidativestress,Thalidomide,Tamoxifenandasbestosproliferators,domoicacid,bonemarrow(benzene),heart(adriamycin),blood(primaquine),biomarkers,cytochromeP450andotherenzymes,receptormediatedeffects,endocrinedisruption,ethanol,botox,arsenic,andmorequestionswithanswersforeachchapterforreviewandself-checkingexpandedandupdatedchapterbibliographiesd◎内容截图Prefacev1.Introduction11.1Background11.2Scope21.3BiochemicalAspectsofToxicology2Summary4ReviewQuestions4Bibliography52.FundamentalsofToxicologyandDose-ResponseRelationships72.1Introduction72.2Biomarkers72.3CriteriaofToxicity82.4NewTechnologies112.5EvaluationofToxicity112.6Interactions142.7DoseResponse162.8MeasurementofDose-ResponseRelationships202.9LinearDoseResponse252.10Hormesis262.11HazardandRiskAssessment272.12DurationandFrequencyofExposureandEffect31Summary32ReviewQuestions32References32Bibliography333.FactorsAffectingToxicResponses:Disposition353.1Introduction353.2Absorption353.3SitesofAbsorption433.4Distribution533.5Excretion66Summary71ReviewQuestions72References73Bibliography734.FactorsAffectingToxicResponses:Metabolism754.1Introduction754.2TypesofMetabolicChange764.3Phase1Reactions774.4Phase2Reactions1024.5GeneralSummaryPoints1154.6ControlofMetabolism116……7.BiochemicalMechanismsofToxicity:SpecificExamples2937.1ChemicalCarcinogenesis2937.2TissueLesions:LiverNecrosis3087.3TissueLesions:KidneyDamage3277.4TissueLesions:LungDamage3357.5Neurotoxicity3397.6ExaggeratedandUnwantedPharmacologicalEffects3457.7PhysiologicalEffects3547.8BiochemicalEffects:LethalSynthesisandIncorporation3587.9BiochemicalEffects:InteractionwithSpecificProteinReceptors3617.10Teratogenesis3677.11Immunotoxicity3737.12Multi-OrganToxicity3837.13Multi-OrganToxicity:Metals386Summary392ReviewQuestions401References402Bibliography403Glossary409Answerstoreviewquestions423Index439